Services


Renal progenitor cells – Urine Derived

UriCell uses urine as an innovative source for the isolation of renal stem cells originating from the kidney. Amongst these are podocytes, renal progenitor cells, renal, parietal and renal epithelial tubular cells. Compared to other stem cell sources such as bone marrow, cord blood or amniotic fluid, urine is unlimited and easily accessible. It is not associated with any risks/pain for the donor because the method is non-invasive (in contrast to biopsies). UriCell provides service for industrial and academic research, offering renal cell product-based platform technology which can be used for drug testing and nephrotoxicity studies.

  • Personalized: UriCell can source a urine sample for urine-derived cell line generation
  • Off-the-shelf: UriCell distributes existing urine-derived cell lines

Induced pluripotent stem cells (iPSCs) – Urine Derived

Renal cells isolated from urine from all individuals can be reprogrammed, e.g. by nucleofection of a combination of two episomal-based plasmids omitting pathway (TGFB, MEK and GSK3B) inhibition. The induced pluripotent stem cells (iPSCs) can be characterized by immunocytochemistry, embryoid body formation, DNA-fingerprinting and karyotype analysis. Comparative transcriptome analyses with human embryonic stem cell lines H1 and H9 demonstrates high similarity by Pearson correlations of 0.92-0.99.

  • Personalized: UriCell can source a urine sample for iPSC line generation
  • Off-the-shelf: UriCell distributes existing urine-derived iPSC lines

To complete our services CYP2D6 analysis and HLA typing can be provided.


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